This is another example of lymphoma cells circulating in the peripheral blood. In this case, the lymphoma cells were called blasts because of the paucity of cytoplasm and the relatively fine nuclear chromatin. Recirculating in the peripheral blood are a relatively late development in the course of lymphoma and almost always indicate marrow involvement. Some workers feel that the appearance of circulating lymphoma cells with blastic cytlogy heralds the development of new clinical problems, such as increased neutropenia and thrombocytopenia, whereas the appearance in the peripheral blood of more normal-appearing lymphocytes is not as ominous.
Course Section: 07. Lymphocytic Leukemia: Acute and Chronic
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