This slide shows still another case of CLL, characterized by many more abnormal lymphocytes that were seen in the previous cases. These abnormal lymphocytes are larger than mature lymphocytes, have a less clumped, more reticulated chromatin pattern, often contain fairly large, prominent nucleoli, and have nuclei with round to markedly notched configurations. Some hematologists have called these "lymphosarcoma cells" to distinguish them from the more normal-appearing CLL lymphocytes.
Course Section: 07. Lymphocytic Leukemia: Acute and Chronic
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