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Slide 26
A clinical condition called "prolymphocytic leukemia" was described in 1974 by Galton and coworkers (see Suggested Readings). The peripheral blood picture in these cases resembles that of the so-called chronic lymphosarcoma cell leukemia; the abnormal lymphocytes probably are best characterized by very prominent nucleoli, as seen here. The diagnosis of prolymphocytic leukemia is dependent on a patient's clinical presentation as well as the cytological findings of the peripheral blood. These patients generally have marked splenomegaly without much lymphadenopathy.

Course Section: 07. Lymphocytic Leukemia: Acute and Chronic
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