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Slide 21
Here is another bone marrow aspirate obtained from a patient with CLL. The lymphocyte infiltration in this example is much less marked than in the previous case. Bone marrow biopsies from cases of CLL often show a diffuse lymphocytic infiltrate, although more focal aggregations may be observed. However, collections of lymphocytes lymphoid nodules) can occur in normal bone marrow biopsy specimens also, so the diagnosis of CLL cannot be made on the basis of bone marrow lymphocytosis alone.

Course Section: 07. Lymphocytic Leukemia: Acute and Chronic
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