This slide allows a direct comparison between the blasts in a case of L1 ALL (left) and those from a patient with L2 ALL (right). The L1 blasts are relatively small and have indistinct nucleoli and remarkably little cytoplasm. In contrast, L2 blasts are heterogeneous in all respects, including cell size and shape, nuclear size and shape, presence and conspicuousness of nucleoli, and amount and staining of the cytoplasm. In spite of the differences shown here, some workers (see Viana, Maurer, and Ferenc in the Suggested Readings) found that about 10% of their cases of ALL could not be readily classified as either L1 or L2.
Course Section: 07. Lymphocytic Leukemia: Acute and Chronic
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