Shown here is a segmented neutrophil with toxic granulation. The granules are larger and darker than those usually seen in segmented neutrophils. These are azurophilic granules left over from the progranulocyte. They represent immaturity resulting from rapid turnover of cells. They are seen primarily in patients with infections and leukemoid reactions. In the normal maturation of granulocytes there is a change in the staining properties of the azurophilic granules from the promyelocyte to the myelocyte stage, which make them invisible in older granulocytes stained with Wright's stain.
Course Section: 03. Blood Smears Stained with Wright's Stain
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