This slide was made from a patient with Chediak-Higashi anomaly. The granulocytes contain extremely large granules resulting from abnormal fusion of granules during their formation. The abnormal granules are found in cells in many sites in the body: skin, ocular pigment, adrenal and pituitary glands, peripheral nerves, gastrointestinal organs, and elsewhere. Patients with this autosomal recessive disorder have ocular and cutaneous albinism, and increased susceptibility to pylogenic infections. I have seen similar fusion of granules, probably an acquired defect, in two patients with chronic granulocytic leukemia.
Course Section: 03. Blood Smears Stained with Wright's Stain
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