The nucleated red blood cells indicated by the arrows in this bone marrow stained for iron are ringed sideroblasts. The mitochondria, which form a crown around the nucleus, contain iron. It is often asked how far must the crown extend around the nucleus for the cell to be a ringed sideroblast; It should extend at least halfway around. Ringed sideroblasts are seen in the bone marrow of patients with heavy metal intoxication, pernicious anemia, and other dysery-thropobetic disorders.
Course Section: 02. Inclusions Found in Red Blood Cells
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