The red cells seen here, which contain blue inclusions, are reticulocytes. Reticulocytes are the stage of maturation between the extrusion of the nucleus and the mature erythrocyte. They still contain mitochondria and ribosomes. The inclusions are precipitated ribosomes that have first been stained vitally with new methylene blue before spreading on a glass slide. Young reticulocytes have more ribosomes than do old ones, and you may see only two or three precipitates in the latter. The most important fact to remember about reticulocytes is that they are our best measure for assessing the rate of effective erythropoiesis in the bone marrow.
Course Section: 02. Inclusions Found in Red Blood Cells
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