An inclusion frequently seen in the blood smear is a Howell-Jolly body. One is seen in the red cell indicated by the arrow. They are round, stain bluish-red, and usually there is only one per cell. Howell-Jolly bodies are nuclear fragments and can be verified by nuclear stains, such as the Feulgen reaction for DNA. They are present in hemolytic anemia, megaloblastic anemia, hyposplenism, and following splenectomy for any cause. The spleen has the ability to remove foreign bodies from red cells, leaving the red cell intact. The most frequent occurrence of Howell-Jolly bodies in our laboratory is following splenectomy for staging of Iymphoma and splenectomy during renal transplant.
Course Section: 02. Inclusions Found in Red Blood Cells
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