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Slide 8
Shown here is one of the most frequent abnormalities seen in blood smears. It is a nucleated red blood cell. A blood smear is abnormal if even one nucleated red cell is seen. They are most commonly observed in hemolytic anemias of all kinds, myelofibrosis, leukemia and other myeloproliferative disorders, and myelophthisic anemias. They are less common in dyserythropoiesis, megaloblastic anemias, severe iron deficiency, sepsis, severe hypoxia, cardiac failure, after bleeding, and after splenectomy. Normoblasts are counted in a blood smear differential but they are not included in the 100 white cells. The nucleated red blood cells are reported as number/100 WBCs.

Course Section: 02. Inclusions Found in Red Blood Cells
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