The cells indicated by the arrows contain basophilic stippling. The stippling is in polychromatic red cells and is peppered over the entire cell. Basophilic stippling or punctate basophilia is seen in smears stained with Wright's. The granules may be fine or coarse. Stippling is formed during the drying of the smear. Stippling is not found in living cells but may be produced in the test tube. It is variable in slides made from the same tube of blood. It is seen in lead poisoning and many anemias with disordered hemoglobin synthesis. Stippling is not seen in smears made from normal blood. The granules consist of precipitated ribosomes and polyribosomes the same as reticulocytes except that the latter must be precipitated vitally. As mentioned previously, reticulocytes roughly correlate with diffuse polychromasia.
Course Section: 02. Inclusions Found in Red Blood Cells
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