These two lymphocytes are abnormal. The lymphocyte on the left has two nuclei, one larger than the other, and the lymphocyte in the middle has a cleft through the center of the cell. Both cells have heavy, clumped nuclear chromatin and scanty cytoplasm. The slide was made from a patient with lymphoma and these cells are typical for this disease, although a few cells similar to these can be seen in some cases of chronic lymphocytic leukemia. These lymphocytes sometimes are referred to as "notched" cells.
Course Section: 04. Immature Cells in the Granulocytic - Monocytic - and Lymphocytic Series
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