There are six stages of maturation in the myelocytic series. The eosinophilic and basophilic lines follow the same stages as the neutrophiiic. The cell shown here is a myeloblast. Myeloblasts have two to six light-colored nucleoli. The imagination must be used at times in counting the number of nucleoli in cells stained with Wright's stain, unless a well-defined nuclear membrane is seen. Vacuoles can be mistaken for nucleoli. Myeloblasts generally have regular, round nuclei with fine, unclumped chromatin. The nucleus-to-cytoplasm ratio (N:C) is usually between 8:1 and 6:1. The cytoplasm is basophilic at the rim with a lighter staining area around the nucleus. A myeloblast contains no granules. Note the red rod in the cytoplasm in this cell. It is an Auer rod. Auer rods are found almost exclusively in leukemia. They are limited nearly entirely to cases of nonlymphocytic leukemia.
Course Section: 04. Immature Cells in the Granulocytic - Monocytic - and Lymphocytic Series
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