This slide was made from the bone marrow smear of a 62-year-old man treated for MM with melphalan and prednisone pulses at six-week intervals for three and one-half years. The marrow is diagnostic of acute leukemia. Approximately 5% of cases of MM terminate with acute leukemia that is usually myelomonocytic. It is not certain if melphalan causes the leukemia or if patients live longer because of treatment and leukemia develops coincidentally.
Course Section: 10. Plasma Cell Dyscrasias
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