This slide is from the bone marrow of a patient with HCD. The bone marrow in HCD may contain lymphocytes and plasma cells with extremely large vacuoles. Marked changes may occur in lymph nodes consisting of pleomorphic infiltration of plasmacytic, lymphocytic histiocytic, and eosinophilic cells. The clinical, morphologic and laboratory features of HCD vary with the type of heavy chain produced, but the disease resembles lymphoma rather than myeloma. Symptoms include weakness, recurrent fever, and marked susceptibility to bacterial infections. Physical examinations reveal lymphadenopathy and hepatosplenomegaly. No radiographic skeletal abnormalities are noted. The diagnosis is confirmed by IEP.
Course Section: 10. Plasma Cell Dyscrasias
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