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Slide 30
Amyloidosis is a condition characterized by the accumulation of protein fibrils in various body organs and eventually leading to organ dysfunction. A classification of the different types of amyloid is shown in Table 5. Deposits of amyloid are found in 10%-15% of MM cases, usually associated with light chain MM. In light chain MM and in primary and localized amyloidosis, the fibrils consist of polymers of lambda or kappa light chains. In secondary amyloidosis, protein A is present in the fibrils. Amyloid fibrils can be demonstrated in tissue by a characteristic apple-green birefringence when Congo red stain is used. The majority of patients with amyloidosis will have either SPE or IEP abnormalities, and the incidence of Bence Jones proteinuria approaches 90%.

Course Section: 10. Plasma Cell Dyscrasias
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