In attempting to make a diagnosis of MM from the bone marrow, one looks for clumps of plasma cells. In fact, it is difficult to make the diagnosis if clumps are absent. How many plasma cells constitute a clump? The clumps may vary from five to six cells to sheets of cells. Notice too in this slide that the plasma cells contain nucleoli. Note also that there are normal bone marrow cells in this field. The distribution of plasma cells is extremely variable, and at times more than one particle must be examined for the presence of plasma cells. In some areas of a slide the bone marrow may be normal.
Course Section: 10. Plasma Cell Dyscrasias
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