In the center of the field are two plasma cells. The lower cell is a mature normal plasma cell. The cell above it is an immature plasma cell or proplasmacyte. This cell is larger than the mature one. The nuclear chromatin is more evenly dispersed and the Golgi body is not as prominent. When diagnosing malignant plasma cell dyscrasias, we look more for abnormalities in the cells and their numbers than for cell stages of maturation. We look for abnormalities in size, asynchrony of cytoplasm and nucleus, nucleoli, increased nucleus-to-cytoplasm ratio, indistinct Golgi bodies, and large vacuoles.
Course Section: 10. Plasma Cell Dyscrasias
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