Shown in this slide are examples of IEPs. Each shows the arc for the gamma and the alpha heavy chains and the kappa and the lambda light chains. Pattern 1 is a normal study; note the smooth, slightly curved arcs. The light chain studies usually look similar to the IgG distribution since IgG is found in greater amounts than IgA or IgM; also the light chains in IgA and IgM may have reduced reactivity to antisera. Pattern 2 shows an IgG-kappa paraprotein. Note the extra arc in IgG and kappa, both arcs are at the same position. Pattern 3 is an IgA-kappa paraprotein. Occasionally one will see two extra arcs of light chain, one bound to a heavy chain and the other circulating free (BJP).
Course Section: 10. Plasma Cell Dyscrasias
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