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Slide 8
Note the thin area in the indentation of the nucleus of this cell. It is a useful sign for identifying monocytes in acute leukemia. In laboratory we refer to this sign as the "dough" sign because it looks like a loaf of bread dough that has been pushed in with a fist. The dough sign is specific for monocytes but is seen primarily in blasts.

HEMATOLOGY
Course Section: 09. Acute Myelomonocytic Leukemia - Monocytic Leukemia - and Erythroleukemia
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