On the left of this slide is a Wright's-stained smear containing a cell with a red rod in the cytoplasm. This red body is an Auer rod. On the right of the slide is a cell containing Auer rods stained for myeloperoxidase (MPX) activity. Auer rods are nearly 100% diagnostic of an ANLL. They should be sought in the blood and bone marrow if ANLL is suspected. Auer rods are not always as thick as the one shown on the left; they may be thin, and often there is more than one in a cell. Auer rods are derived from an abnormal fusion of azurophilic granules. True Auer rods can be differentiated from the red rods seen in lymphocytes and plasma cells, as the latter have no reaction with MPX.
Course Section: 09. Acute Myelomonocytic Leukemia - Monocytic Leukemia - and Erythroleukemia
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