ANLL is a condition in which 50% of the cells in the bone marrow are either myeoblasts, promyelocytes, monoblasts, promonocytes, or monocytes. ALL has been discussed in the program Lymphocytic Leukemia: Acute and Chronic in this series.
The FAB classifications for the ANLLs are listed in Table 1. It is based on the bone marrow morphology of cells assayed by cytochemical stains. M1 is acute myelocytic leukemia (AML) without maturation. M2 is partially differentiated AML with more than 50% of the cells myeloblasts and promyelocytes and with myelocytes and metamyelocytes present. M3 is acute promyelocytic leukemia (APL) with more than 30% promyelocytes. M4 is acute myelomonocytic leukemia (AMML), which resembles M2 except that approximately 25% of the cells are myeloblasts and promyelocytes and 25% are monoblasts and promonocytes/monocytes. The acute monocytic leukemias (AMoL) are divided into two groups: M5a without maturation, and M5b with partial maturation. M6 is erythroleukemia (EL) with greater than 50% total NRBCs and with many of the erythroblasts having bizarre features. Only the last three of these classes will be discussed in this program since the first three were included in the program Myelocytic Leukemia: Chronic and Acute in this series.
Course Section: 09. Acute Myelomonocytic Leukemia - Monocytic Leukemia - and Erythroleukemia
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