The large cells in this slide are both E2 cells or basophilic normoblasts. These cells are slightly smaller in size than the E1 cells. The nuclear chromatin is beginning to aggregate. Actually, the only definite difference between E1 and E2 is the clumping of the nuclear chromatin and the prominent, dark, irregularly shaped chromocenters. These dark, irregular, fused chromocenters in early NRBCs are another helpful finding in differentiating between young red cells and young white cells. The top cell in this picture has a little hemoglobin in the cytoplasm that gives it a muddy, brownish appearance. Note the light spot in the cytoplasm in the lower cell.
Course Section: 05. Nucleated Red Blood Cells
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