This is a higher magnification of a bone marrow of a patient with refractory megaloblastic anemia. The NRBCs appear megaloblastic, with a deficiency of nuclear chromatin. However, the granulocytes are normal. The patient failed to respond to a trial treatment with B12 and folate. Dyserythropoiesis may be congenital or acquired. Examples of dyserythropoiesis are sideroblastic anemia, leukemia, preleukemia, erythroleukemia, thalassemia, iron deficiency, and aplastic anemia.
Course Section: 05. Nucleated Red Blood Cells
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