This is the iron stain (Perls' reaction) of a bone marrow from a patient with refractory sideroblastic anemia. The iron stains bluish. It is normally present in the phagocytic cells and as granules in NRBCs. The presence of ringed sideroblasts indicates disordered and ineffective erythropoiesis. In ringed sideroblasts the iron is deposited in mitochondria around the nucleus.
Course Section: 05. Nucleated Red Blood Cells
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