The cell indicated by the arrow is an E4 cell or polychromatophilic normoblast. It is the last cell of the series that will undergo mitosis. The cell is smaller than the ones shown in the previous slides. The nuclear chromatin is quite clumped and the cytoplasm definitely contains more hemoglobin and much less RNA. It is at this stage of maturation that many of the abnormalities of NRBCs become marked and distinctive. The other cell in the field is an E5 cell.
Course Section: 05. Nucleated Red Blood Cells
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