Diagnosis of Di Guglielmo's syndrome depends upon the presence of multinucleated NRBCs. The large E4 cell indicated by the arrow has four nuclei. To say that a patient has Di Guglielmo's syndrome, abnormal multinucleated erythroid cells must be present in the bone marrow. In patients with Di Guglielmo's syndrome there is a notable shift to younger forms of the white cell series, which may be myelocytic or monocytic.
Course Section: 05. Nucleated Red Blood Cells
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