The diagnosis of CML depends on both the clinical and the laboratory findings. A description of the clinical findings can be found in any hematology textbook. The laboratory findings in Table 1 include hypercellular bone marrow with myelocytic hyperplasia and a relative decrease in nucleated red blood cells (NRBCs). The LAP is decreased, and the Philadelphia chromosome (Ph1) is present. Basophilia and eosinophilia of variable degrees are present in both bone marrow and blood. The total white blood cell count is usually greater than 30,000/cu mm. The hematologist knows that all of these features are not present in each patient. For example, cases of CML have been reported without the Ph1 chromosome, and others have had normal LAP scores.
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Course Section: 08. Myelocytic Leukemia: Chronic and Acute
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