This is the bone marrow, photographed at 700x magnification, from a patient with CML. There is one basophil in this field. If basophils are rare or absent from the bone marrow, diagnosis other than CML should be entertained. Notice also there seems to be about an equal number of segmented neutrophils and myelocytes. Usually in CML there are two peaks in the cell differential, consisting of segmented neutrophils and myelocytes and fewer band forms, metamyelocytes, and promyelocytes. Generally there are less than 5% blasts. The main differences between normal bone marrow and CML bone marrow are the cellularity and the myeloid-to-erythroid (M:E) ratio.
Course Section: 08. Myelocytic Leukemia: Chronic and Acute
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