Two small megakaryocytes found in the blood of a patient with CML are shown here. Small megakaryocytes often are missed in the blood and sometimes are wrongly called lymphocytes. The nuclei are round or oval with fine, smooth chromatin patterns that are more lightly stained than those of lymphocyte nuclei. The megakaryocytes, sometimes called megakaryocytic fragments, may have definite cytoplasmic membranes, or the cytoplasm may be sparse and irregular without membranes. The cytoplasm may or may not contain platelets. Also, when megakaryocytes are present in the blood, thrombocytosis and megathrombocytosis usually occur.
Course Section: 08. Myelocytic Leukemia: Chronic and Acute
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