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Slide 21
This cell is a promyelocyte. The N:C ratio is about 4:1. The chromatin is heavier than that seen in the blast. The nucleus is generally regular in shape, ie, round or oval, but may be irregular. It is often eccentric. The nuclear chromatin is slightly aggregated. There are five indistinct light-staining nucleoli in this cell. The cytoplasm of a promyelocyte is basophilic, and it may appear even more basophilic than that of a blast because it has no light perinuclear zone. The cytoplasm of a promyelocyte contains a variable number, from one to many, of azurophilic granules.

HEMATOLOGY
Course Section: 08. Myelocytic Leukemia: Chronic and Acute
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