This bone marrow, photographed with the 10x objective, was obtained from a patient with CML. It is hypercellular with very little fat. Fat is estimated by the number and size of the holes where it has been dissolved by the alcohol in the stain. The bone marrow has an increased number of megakaryocytes. A normal marrow usually has 3 to 10 megakaryocytes in a field at this magnification; over 20 in a field is abnormal. Generally the number of megakaryocytes is increased and thrombocytosis occurs in the early stage of the disease.
Course Section: 08. Myelocytic Leukemia: Chronic and Acute
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