Gaucher cells characteristically are seen in Gaucher's disease, a hereditary lipid storage disease. The cell indicated by the arrow is a Gaucher cell present in the bone marrow of a patient with CML. Gaucher cells may be formed as a result of the destruction of many leukemic cells, which normally are degraded by the phagocytic histiocytes. Gaucher cells are large cells with one or two small eccentric nuclei that have condensed nuclear chromatin. The abundant cytoplasm appears empty except for thin thread-like strands. A similar type of cell that may be formed in CML is the sea-blue histiocyte. The mechanism for its formation probably is similar to that of the Gaucher cell.
Course Section: 08. Myelocytic Leukemia: Chronic and Acute
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