This is the blood smear from the same patient as in slide 9. A basophilic myelocyte is indicated by the arrow. Generally the blood and bone marrow differentials are quite similar. In fact, it is easier to make a diagnosis from the blood than it is from the bone marrow. Furthermore, a diagnosis cannot be made on the basis of the bone marrow alone; the typical findings for the blood are also needed. Why then should one do a bone marrow in patients with CML? It is done to determine the amount of fibrosis and to obtain material to look for the Ph1 chromosome. If the bone marrow has a normal M:E ratio, the diagnosis of CML can practically be excluded.
Course Section: 08. Myelocytic Leukemia: Chronic and Acute
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