Osteoblasts, nonhematopoietic cells, two of which are pictured here, are often seen in bone marrow of children. The cells are somewhat like plasma cells except that they are larger and more elongated. The color of the cytoplasm is similar to that of plasma cells. The light circular area seen in plasma cells adjoining the nucleus is distal to the nucleus in osteoblasts. Another difference is the cytoplasmic vacuoles that are present in plasma cells but that are not seen in osteoblasts. Osteoblasts usually occur in clumps but may be seen singly.
Course Section: 06. Microscopic Examination of the Bone Marrow
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