The two large cells shown here are foamy histiocytes. They are seen most often in liver disease. They are similar to the cells seen in Niemann-Pick and Hand-Schuller-Christian disease, which are congenital storage diseases. The histiocyte has one nucleus that contains heavy chromatin. The cytoplasm contains droplets of fat that stain poorly with Wright's stain.
Course Section: 06. Microscopic Examination of the Bone Marrow
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