Note the extreme amount of anisocytosis and poikilocytosis, as well as microspherocytosis and budding of the red cell membranes in this blood smear made from a patient with congenital hemolytic anemia. The cells of such patients are especially fragmented by heating at 45 C for 15 minutes, while normal red cells require incubation at 49 C before fragmentation occurs. The basic defect of the red cell membrane is not known. The patients with this disorder present with anemia, elevated reticulocyte counts, splenomegaly, and red blood cells as shown here.
Course Section: 01. Description of Red Blood Cells
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