Normal blood is shown on the right and the blood from a patient with pernicious anemia on the left. Notice the large ovalocytes typical of megaloblastic anemia. Macrocytic cells ususally are seen in patients with B12 or folic acid deficiency, but can be seen in other conditions such as myeloid metaplasia, refractory megaloblastic anemia, liver disease, hypothyroidism, and after treatment with some antimetabolites.
Course Section: 01. Description of Red Blood Cells
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