The cell indicated by the arrow is called a stomatocyte, from the Greek word meaning mouth. Stomatocytes have a rectangular central pale area similar to a coin slot. Instead of being biconcave, a stomatocyte has only one cavity and with scanning electron microscopy appears cup-shaped. Stomatocytes often are seen in normal blood, as shown here, and in greater numbers in liver disease and other anemias. They may be produced in the laboratory by hypotonic solutions. A rare hereditary hemolytic anemia is diagnosed by the presence of large numbers of stomatocytes (see Lock et al in the Suggested Readings).
Course Section: 01. Description of Red Blood Cells
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