The principal types of spicule formation and the diseases associated with them are found in Table 3. These will be demonstrated in the next series of photomicrographs. The most important thing to remember about spicule formation is that liver disease should be considered first if target cells and acanthocytes are seen, and renal disease if many schistocytes and burr cells are present. If these two conditions are ruled out, then consider the other conditions associated with spicule formations, such as hemolytic anemia, heart valve replacement, disseminated intravascular coagulation (DIC), vasculitis, and others.
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Course Section: 01. Description of Red Blood Cells
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