The blood shown here is from a patient with autoimmune hemolytic anemia. Spherocytes are seen in this disease as often as in hereditary spherocytosis. In fact, it is impossible to distinguish between the two from a slide of blood only, and other tests are needed to differentiate between them. The red cells must be darker than normal cells to be called spherocytes and they should not be confused with cells without a central pale area and the same color as the normal cells.
Course Section: 01. Description of Red Blood Cells
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